Post-doc position to work in Dr. Chen's laboratory: Novel metabolic protein confers resistance to irradiation and oxidative stress
Description: Research in my laboratory focuses on understanding the biologic principles that govern the pathogenesis of glioblastoma, the most common form of brain cancer. The long term goal is to translate these fundamental biologic principles into clinically useful therapeutic strategies and diagnostic tools.
A major project in my lab is to investigate the novel function of metabolic protein in the regulation of DNA damage response. Tumor cells display high rate of metabolism, including elevated glucose uptake and enhanced lactic acid production aerobic conditions, in terms of Warburg effect. Multiple metabolic proteins, including lactate dehydrogenase A (LDHA), have been shown to be involved in the cell growth and tumor progression. Our recent study has shown that LDHA could translocate to nucleus, alter chromatin structure and confer resistance to irradiation and oxidative stress.
In my laboratory, we study cancer metabolism, tumorigenesis, and tumor progression, focusing on the following research topics:
1. Identify and validate functional partners of LDHA in nucleus to alter chromatin structure upon irradiation and oxidative stress, which contributes to the elevated resistance; 2. Identify particular DNA sequence recognized by LDHA upon irradiation and oxidative stress; 3. Investigate the pathways which facilitate LDHA nuclear translocation; 4. Long term goal is to study the regulation of LDHA in the crosstalk between tumor cells and microenvironment
Doctoral Degree required, preferably in Molecular, Cellular Biology or other related areas. Expertise in cellular biology, molecular biology, bioinformatic, immunohistochemistry, shRNA screening, lenti-/retro-virus production, and mouse models are preferred. Candidates should demonstrate superior motivation, and possess excellent oral and written communication skills. Salary based upon experience.
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