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Post Doc Instructions:
Please do not submit an application to this posting. To apply for this postdoctoral research opportunity, follow the directions below in “Applicant Special Instructions”.
This position is full-time, hours are generally normal business hours but may vary due to the timing for research experiments.
Department Name/Job Location:
This position is in the Department of Internal Medicine Cardiology Division and is located in the McDonnell Sciences building on the Medical School Campus.
A postdoctoral research fellowship position is available in the laboratory of Dr. Stacey Rentschler at Washington University School of Medicine. Our lab investigates the transcriptional and epigenetic mechanisms regulating programming of electrophysiological phenotypes. Our group demonstrated that reactivation of developmental signaling pathways including Notch and Wnt can electrically remodel cardiomyocytes, or “reprogram” them, to adopt a new electrical phenotype in animal models (Rentschler et al, Journal of Clinical Investigation, 2011; Rentschler et al, Circulation, 2012; Gillers et al, Circulation Research 2015). In heart failure, reactivation of the Notch signaling pathway may contribute to transcriptional changes influencing ion channel gene expression that may predispose to the development of lethal arrhythmias (Khandekar et al, Circulation Research 2016). In contrast, reactivation of distinct signaling networks within adult myocardium may provide new avenues for regenerative medicine approaches for the treatment of arrhythmias, such as in the development of a biological pacemaker (Meyers et al, Trends in Cardiovascular Medicine, 2015).
Together with our collaborators, we have developed methodology for culturing organotypic cardiac slices from atria and ventricles from explanted human donor hearts rejected from transplantation. Functional readouts include optical mapping with voltage-sensitive dyes to visualize and quantify electrophysiological properties, as well as microelectrode recordings to assess changes in cellular physiology. In addition, we are performing genome-wide gene expression and epigenetic studies on mouse and human cardiac tissue to decipher the complex regulatory mechanisms that govern expression of important regulators of electrophysiology within regions of the heart in both health and disease states. This methodology will allow us to test the response of human cardiac tissue to selected therapeutics, with the goal of expediting the prolonged process involved in getting new therapeutics validated for use in humans.
Highly motivated candidates who have a track record of productivity, work well independently, and also enjoy working together on a team are encouraged to apply. The successful applicant will be responsible for executing experiments involved handling of human tissue, as well as working with mouse models.
The hiring range for this position is commensurate with experience.
This position is eligible for full-time benefits. Please visit our website at http://hr.wustl.edu to view a summary of benefits.
Applicant Special Instructions:
Interested candidates should email a single pdf file that includes a cover letter and CV together with the names of two referees with contact information to:
Stacey Rentschler, MD, PhD
Ph.D. candidates who will graduate soon, or have recently completed their doctoral degree are encouraged to apply.
Internal Applicant Instruction:
Please attach a copy of your most current signed performance evaluation (completed within the last 18 months) to your online account. If you have not received a performance evaluation, you may provide two current signed letters of recommendation (written within the last 18 months), preferably to include one letter from either a current or recent former supervisor. To attach these documents, go to: My Career Tools, Add Attachment, Attachment Type – Performance Reviews or Letters of Recommendation.
The appointee has earned a Ph.D., M.D. or equivalent terminal or doctoral degree.
Candidates with extensive background in gene expression and/or epigenetics are strongly preferred.
Washington University in St. Louis, a medium-sized, independent university, is dedicated to challenging its faculty and students alike to seek new knowledge and greater understanding of an ever-changing, multicultural world. The University offers more than 90 programs and almost 1,500 courses leading to bachelor's, master's and doctoral degrees in a broad spectrum of traditional and interdisciplin...ary fields, with additional opportunities for minor concentrations and individualized programs. The faculty is composed of scholars, scientists, artists and members of the learned professions. They serve society by teaching; by adding to the store of human art, creativity, understanding, and wisdom; and by providing direct services, such as health care.