The postdoctoral scholar is responsible for independent and collaborative development, implementation, and analysis of scientific research in the discipline of biochemistry and molecular biology to conduct hypothesis-driven cancer research centering on sphingolipid metabolism as it relates to growth control and therapeutics.
Responsibilities include management of all aspects of studies related to targeting sphingolipid metabolism as a therapeutic approach to cancer treatment. The postdoctoral scholar will investigate ceramide metabolism in leukemia as it relates to growth control with a focus on therapeutics and drug resistance. The applicant will be employing skills in the areas of tissue culture, cell biology, pharmacology, enzymology, molecular biology, lipid biochemistry, and enzyme expression, and be knowledgeable in cell signaling pathways involved in apoptosis and autophagy. Experience in mitochondrial biology (respiration, bioenergetics), glycolysis (Seahorse), cell cycle traverse, and flow cytometry is desired. Duties include: hypothesis development, literature review, collection of pilot data, report writing, and supervising of undergraduate research students and graduate research students, overseeing data collection procedures, supervising experimental procedures, review of data for quality control, supervision of data entry/data analysis, analysis of research hypothesis using descriptive and multivariate statistics, and the development of independent and collaborative presentations and publications.
The successful applicant will join a research team studying sphingolipid/ceramide metabolism in leukemia as it relates to growth control with a focus on therapeutics and drug resistance. The applicant will be employing skills in the areas of tissue culture, cell biology, pharmacology, enzymology, molecular biology, lipid biochemistry, and enzyme expression, and be knowledgeable in cell signaling pathways involved in apoptosis and autophagy. Experience in mitochondrial biology (respiration, bioenergetics), glycolysis (Seahorse), cell cycle traverse, and flow cytometry is desired. Scholars are expected to demonstrate compliance with established guidelines and regulatory standards for research including biosafety, responsible conduct of research and human subjects training.
Approximately 80% of the postdoctoral scholar's time will be devoted to independent experimentation.
Approximately 20% of the postdoctoral scholar's time will be devoted to managing day-to-day administrative activity including tabulating data in graphic form, writing and reading manuscripts and grant applications for submission, and guiding undergraduate and graduate research students in the laboratory.
Special Instructions To Application:
To be considered for this position, all applicants must apply through PeopleAdmin and attach their CV or resume, cover letter and names and contact information of 3 references. Appointments are typically for a one year period. Five years (typically five appointments of one year) is typically the maximum total period that any individual may serve as a Scholar. The University, in its sole discretion has the option to renew or extend any appointment, subject to the availability of funds, past performance evaluations and/or any other lawful reasons. For other information on the ECU Office of Postdoctoral Affairs, please visit our website at: http://www.ecu.edu/postdoctoralaffairs/
English proficiency Excellent written and oral communication skills PhD in biochemistry and/or molecular biology, or MD/PhD with thesis work in biochemistry and molecular biology.
Full time or Part time: Full Time
Position Location (city): Greenville
Position Number: PDS-BIOC-11-17
Organizational Unit Overview:
The Department of Biochemistry and Molecular consists of 10 full-time faculty members that includes some fixed term faculty and one school administrator, 7 full-time Research Specialists, 1 full-time Research Technician, two full-time office Administrators and eight graduate students.
The department teaches Biochemistry to medical and dental students and provides instruction in Biochemistry and Molecular Biology to graduate students from multiple departments. A wide variety of specialized courses for graduate students are also taught. The educational objective of the department is to provide a sound basic foundation for students from various disciplines. The graduate program through the Ph.D. in Biomedical Sciences with a Concentration in Biochemistry and Molecular Biology is broadly based to prepare students for careers in academics, research, government, industry and medicine.
In addition to their teaching duties, each of the faculty members has a research laboratory and is expected to perform research in his/her area of expertise. Faculty are expected to apply for grant support and to publish results of their research in professional journals.
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