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Position Summary: We have an exciting opportunity to join our team as a Research Scientist.
In this role, the successful candidate will devise and execute detailed mechanistic studies to interrogate the molecular mechanisms by which ATDC drives bladder cancer tumorigenesis in genetically engineered mouse models and human ex vivo model systems. The Simeone laboratory has demonstrated that ATDC is a novel oncogene, which is critical for tumor initiation, invasion, and metastasis, in bladder and pancreatic cancers. ATDC is overexpressed in multiple tumor types, and acts as invasive switch, greatly enhancing invasion in mouse models of human bladder cancer.
Conducts original research to investigate the role of ATDC in bladder cancer progression.
Designs and carries out innovative mechanistic studies using genetically modified mouse models (GEMM), bladder cancer cell lines and their genetically modified variants, including stable cell lines in which the ATDC gene is either overexpressed or knocked out, in order to investigate the unique role of ATDC in bladder cancer progression.
Assists in maintaining the ATDC GEMM mouse colony directed to bladder cancer studies; plans and initiates crosses with other key bladder cancer mouse models, in order to determine how ATDC may collaborate with other oncogenes.
Develops and validates novel 3D invasion assays using human bladder tumors in order to interrogate mechanisms of ATDC action in bladder cancer progression and invasion.
Demonstrates advanced knowledge of the literature regarding bladder cancer initiation, progression, as well as potential new detection and treatment methods.
Initiates, interprets, organizes, executes, and coordinates research assignments critical to the laboratorys long term mission to improve detection and treatment of bladder cancer.
Identifies and resolves technical issues related to ongoing research projects.
Develops research techniques and methodologies, writes new protocols.
Ensures timely and accurate completion of research projects.
Writes and prepares manuscripts for publication; contributes to the preparation of new grant applications in the ATDC and bladder cancer areas.
Spearheads new bladder cancer research projects to better define the role of ATDC and other genes and pathways relevant to bladder cancer progression.
Explores subject area and defines scope and selection of problems for investigation through conceptually related studies or series of projects of lesser scope.
Makes significant contributions to scientific papers in our laboratory/department. Is a resource and co-author for publications and presentations.
Maintains a thorough knowledge of the advances in specialized fields through attendance of scientific conferences.
Makes decisions and recommendations that have a major impact on extensive scientific research activities.
Develops new ideas that promote current research. Exercises a high degree of creativity, foresight, and mature judgment in planning, organizing, and guiding extensive scientific research programs and activities of outstanding novelty and/or importance.
May manage the operations of a lab for the Principal Investigator by supervising Post Docs and technicians. Oversees the maintenance and upkeep of instruments and laboratory facilities.
May provide students and other laboratory personnel with technical guidance and direction in experimental techniques and use of equipment as well as general laboratory practices and safety protocols.
May seek grant funding from external sources in support of their independent research projects with consent of the PI and the Department Chair
May be responsible for research/lab quality control and compliance.
May determine and establish laboratory policies, procedures and practices.
May provide recommendations for equipment purchases and for the redesign of lab space, as needed for bladder cancer investigations.
May coordinate collaborative projects and experimental design between various labs, scientific staff, and collaborators.
May serve on internal committees to help further goals of research projects and bring new expertise to the research program.
Performs other related duties as assigned.
Minimum Qualifications: To qualify you must have a MS Degree and 5 years of professional experience.
Preferred Qualifications: Substantial experience from having completed Post Doc training. Established a record of publications.
Qualified candidates must be able to effectively communicate with all levels of the organization.
NYU School of Medicine provides its staff with far more than just a place to work. Rather, we are an institution you can be proud of, an institution where you'll feel good about devoting your time and your talents.
NYU School of Medicine is an equal opportunity and affirmative action employer committed to diversity and inclusion in all aspects of recruiting and employment. All qualified individuals are encouraged to apply and will receive consideration without regard to race, color, gender, gender identity or expression, sex, sexual orientation, transgender status, gender dysphoria, national origin, age, religion, disability, military and veteran status, marital or parental status, citizenship status, genetic information or any other factor which cannot lawfully be used as a basis for an employment decision. We require applications to be completed online. If you wish to view NYU School of Medicine's EEO policies, please click here. Please click here to view the Federal 'EEO is the law' poster or visit https://www.dol.gov/ofccp/regs/compliance/posters/ofccpost.htm for more information. To view the Pay Transparency Notice, please click here.
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Internal Number: 60441445
About NYU Langone Health
NYU Langone Health, a world-class patient-centered integrated academic medical center, is one of the nation's premier centers for excellence in clinical care, biomedical research, and medical education. Located in the heart of Manhattan, NYU Langone is composed of four hospitals – Tisch Hospital, its flagship acute care facility; Rusk Rehabilitation; the Hospital for Joint Diseases, one of only five hospitals in the nation dedicated to orthopaedics and rheumatology; and Hassenfeld Children's Hospital, a comprehensive pediatric hospital supporting a full array of children's health services across the medical center – plus the NYU School of Medicine, which since 1841 has trained thousands of physicians and scientists who have helped to shape the course of medical history. The medical center's tri-fold mission to serve, teach, and discover is achieved 365 days a year through the seamless integration of a culture devoted to excellence in patient care, education and research. For more information, go to www.nyulangone.org.