University of California, San Francisco Department of Pediatrics
This laboratory investigates the genetics and biochemistry of cancer with an emphasis on relevant mouse models. Our current focus is on Ras signaling in myeloid leukemia and sarcoma biology. Specific goals include: (1) to determine the biochemical mechanisms governing growth, survival and differentiation of malignant cells (2) to identify genes and biochemical pathways that are regulated differently in cancer vs. normal cells; (3) to measure the growth of distinct populations of normal and leukemic bone marrow cells in vivo and in vitro; (4) to harvest murine bone marrow and embryonic fetal liver for transplantation into irradiated recipients; (5) to transplant genetically modified hematopoietic cells into recipient mice; (6) to perform genetic analysis on mouse tissues; and, (7) to test the activity of chemotherapeutic agents, radiation, and new experimental treatments in vivo and in vitro. This position is for an individual who will work primarily with mouse models, with less frequent work involving human cell lines and human patient derived samples. The laboratory attempts to use innovative technology where possible to advance knowledge and increase efficiency.
Required qualifications include: • BS in Engineering or an equivalent combination of education and experience. • Experience presenting own scientific or technical work, orally or in writing. • Familiarity with basic statistical methods (e.g. Student t test, ANOVA, regression, non-parametric tests e.g. Mann-Whitney). • Any experience with computer programming (R or Python preferred), or database design.
Preferred qualifications include: • Experience with: o Laboratory mouse handling: breeding, monitoring, genotyping, blood sampling, anesthesia, intravenous/intraperitoneal injection, dissection. o Flow cytometry and cell sorting (FACS). o Western Blotting (immunoblotting). o Isolation and manipulation of DNA and RNA. o Cell/Tissue culture. o Fluorescence and/or time-lapse microscopy.
Appointees in the Specialist series will be expected to engage in specialized research, professional activities and do not have teaching responsibilities. Specialists are expected to use their professional expertise to make scientific and scholarly contributions, and may participate in University and Public Service. Screening of applicants will begin immediately and will continue as needed throughout the recruitment period. Salary will be commensurate with the applicants experience and training.
UC San Francisco seeks candidates whose experience, teaching, research, or community service that has prepared them to contribute to our commitment to diversity and excellence. The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age or protected veteran status.
The University of California, San Francisco (UCSF) is a leading university dedicated to promoting health worldwide through advanced biomedical research, graduate-level education in the life sciences and health professions, and high-quality patient care. It is the only UC campus in the 10-campus system dedicated exclusively to the health sciences.