Washington University is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity or expression, national origin, genetic information, disability, or protected veteran status.
This position is full-time and works approximately 40 hours per week.
The Hughes Lab is located in the Division of Pulmonary and Critical Care Medicine at Washington University. We are seeking talented applicants for a postdoctoral position studying the effects of systemic inflammation on skeletal muscle.
Chronic Obstructive Pulmonary Disease (COPD) is the third leading cause of death in the United States, and its extra-pulmonary manifestations are a shockingly under-studied contributor to morbidity and mortality. Our lab has recently published (Terry et al. (2018) eLife) the definitive resource of gene expression in skeletal muscle (http://muscledb.org). With these data as a foundation, we are now using functional genomics approaches to study how skeletal muscle reacts to pulmonary disease. We have established a pre-clinical mouse model that recapitulates muscle atrophy due to COPD. Our current projects focus on identifying the cells, genes, and signaling pathways that govern reciprocal interactions between the lungs and muscle. Our long-term goal is to manipulate skeletal muscle for the betterment of human COPD patients. These projects will require the effective use of preclinical mouse models, RNAseq, single-cell RNAseq, muscle physiology and histology, and the analysis of human clinical samples.
PRIMARY DUTIES AND RESPONSIBILITIES:
Assists with grant preparation and reporting.
Prepares and submits papers on research.
Assists in the design of research experiments.
Evaluates research findings and assists in the reporting of the results.
Conscientious discharge of his/her research responsibilities.
Maintain conformity with ethical standards in research.
Maintain compliance with good laboratory practice including the maintenance of adequate research records
Engage in open and timely discussion with his/her mentor regarding possession or distribution of material, reagents, or records belonging to their laboratory and any proposed disclosure of findings or techniques privately or in publications.
Collegial conduct towards co-trainees, staff members and members of the research group.
Adherence to all applicable University policies, procedures and regulations. All data, research records and materials and other intellectual property generated in University laboratories remain the property of the University.
PhD or equivalent in Biomedical sciences.
Comfort and experience working with laboratory mice.
Department Name/Job Location:
This position is in the Department of Internal Medicine, Pulmonary Division. This position is for the Medical School Campus.
Experience in some combination of skeletal muscle biology, bioinformatics, and mouse genetics.
Bioinformatics, R, SQL, Python, etc.
Fluency in molecular biology and mouse genetics.
Ability to work well in a team of scientists from diverse backgrounds.
Base pay commensurate with experience.
This position is eligible for full-time benefits. Please visit our website at http://hr.wustl.edu to view a summary of benefits.
Internal Applicant Instruction:
Please attach a copy of your most current signed performance evaluation (completed within the last 18 months) to your online account. If you have not received a performance evaluation, you may provide two current signed letters of recommendation (written within the last 18 months), preferably to include one letter from either a current or recent former supervisor. To attach these documents, go to: My Career Tools, Add Attachment, Attachment Type – Performance Reviews or Letters of Recommendation.
Applicant Special Instructions:
Candidates should apply by emailing their cover letter, curriculum vitae, and the names of three references to Dr. Michael Hughes at email@example.com.
Post Doc Instructions:
Please do not submit an application to this posting.� To apply for this postdoctoral research opportunity, follow the directions below in �Applicant Special Instructions�.
Washington University in St. Louis, a medium-sized, independent university, is dedicated to challenging its faculty and students alike to seek new knowledge and greater understanding of an ever-changing, multicultural world. The University offers more than 90 programs and almost 1,500 courses leading to bachelor's, master's and doctoral degrees in a broad spectrum of traditional and interdisciplinary fields, with additional opportunities for minor concentrations and individualized programs. The faculty is composed of scholars, scientists, artists and members of the learned professions. They serve society by teaching; by adding to the store of human art, creativity, understanding, and wisdom; and by providing direct services, such as health care.