The Edlow Laboratory is hiring a postdoctoral research fellow!
Our research broadly focuses on the programming effects of maternal obesity/maternal nutrition on fetal and offspring brain development and behavior. We utilize pre-clinical models to explore mechanisms underlying neurodevelopmental morbidity in obesity-exposed offspring, including but not limited to neuroinflammation, neuroimmune interactions, and the impact of offspring sex.
Our laboratory is affiliated with Harvard Medical School and Massachusetts General Hospital. Postdoctoral fellows will have an academic appointment at Mass General Hospital/Harvard Medical School.
Applicant should have a PhD, ideally in neuroscience, although applicants with a PhD and extensive experience with rodent models, molecular techniques, and immunohistochemistry are also encouraged to apply.
The Edlow Laboratory for basic and translational research is sited in the Vincent Center for Reproductive Biology (VCRB) on the main campus of Massachusetts General Hospital. Ongoing studies focus on the neurodevelopmental programming effects of maternal obesity and maternal high-fat diet during pregnancy and lactation. The work is primarily with a mouse model of maternal diet-induced obesity. We evaluate fetal, juvenile, and adult offspring brain development using molecular and immunohistochemical techniques, as well as neurobehavioral testing. Areas of focus include: (1) the effects of maternal diet-induced obesity on offspring cognition and mood outcomes (anxiety, depression), particularly as they relate to neuroinflammation and brain-immune interactions; (2) Developmental programming of offspring feeding behaviors (reward-based feeding governed by the mesolimbic dopamine circuit) and offspring metabolic parameters (including insulin resistance, body fat composition, and dysregulation of leptin, ghrelin, and other peripheral and central hormonal signaling); (3) Utilizing novel targeted therapeutics to improve offspring neurodevelopmental outcomes; and (4) Elucidating the role of fetal and offspring sex in mediating the effects of maternal diet-induced obesity on neurodevelopment.
There are many opportunities for education and growth in our multidisciplinary, collaborative research program that brings together a diverse group of obstetrician-gynecologists, neuroscientists, immunologists, endocrinologists, animal neuroimagers at the world-class Athinoula Martinos Center for Brain Imaging, and translational and clinical researchers at the Women Heart Brain Global Initiative.
Please email a CV and cover letter of interest to Ms. Becky Rogers, Administrative Assistant for the Vincent Center of Reproductive Biology, at email@example.com, indicating that you are applying for the postdoctoral position in Dr. Edlow’s lab.
Two letters of reference and a brief writing sample will also be requested during the interview process.
a PhD is required for the postdoctoral fellow position. However, we are also hiring for a technician position so if you have extensive experience/the skill set below and are interested in a technician position, please also contact us.
- Extensive experience with mouse models and handling, including rodent surgery
- Experience with brain retrieval, tissue preservation for immunohistochemical analyses and RNA/DNA/protein assays, brain sectioning and tissue staining, and neurobehavioral testing is strongly preferred.
-Skill in collection, organization, management, and analysis of complex data sets including record-keeping for large mouse colonies and neurobehavioral test results, among others.
-Skill in experimental design, protocol development, and troubleshooting.
-Skill in data analysis using statistical analytical tools is required. Experience with Graphpad Prism and/or SPSS/STATA/SAS is preferred.
-Experience preparing manuscripts for publication, experience with review and summarization of relevant literature for manuscript background and grant preparation. Preparation of study findings and presentation at professional meetings will also be strongly encouraged.
Internal Number: Edlow Lab 1
About Massachusetts General Hospital/Harvard Medical School
Dr. Edlow is a Maternal-Fetal Medicine physician scientist whose lab is focused on the effects of maternal obesity and maternal nutrition on fetal brain development and offspring behavior. Dr. Edlow is an Assistant Professor of Obstetrics, Gynecology, and Reproductive Biology at Harvard Medical School and a practicing Maternal-Fetal Medicine specialist at Massachusetts General Hospital. Her lab is sited at the Massachusetts General Hospital main research campus, within the Vincent Center for Reproductive Biology.
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