Research Scientist Postdoctoral – Translational Research Institute – Orlando
AdventHealth Orlando seeks to hire a Research Scientist who will embrace our mission to extend the healing ministry of Christ.
Located on a lush tropical campus, our flagship hospital, 1,107-bed AdventHealth Orlando, serves as the major tertiary facility for much of the Southeast, the Caribbean and South America. AdventHealth Orlando houses one of the largest Emergency Departments and largest cardiac catheterization labs in the country. We are already one of the busiest hospitals in the nation, providing service excellence to more than 32,000 inpatients and 125,000 outpatients each year.
The collaborative, multi-disciplinary team of doctors, scientists, and researchers at the Translational Research Institute for Metabolism and Diabetes (TRI) bridges the gap between discovery research and clinical care. This facility, which houses some of the most technologically advanced clinical and diagnostic equipment available, is dedicated to the study of obesity, metabolism, diabetes, and the metabolic origins of cardiovascular disease.
A postdoctoral position is available in the laboratory of Senior Investigator Dr. James P. DeLany. A major focus will include investigation of reasons for the greater risk of diabetes and obesity in African American compared with Caucasian women. PET/CT imaging during a hyperinsulinemic, euglycemic clamp will be utilized to examine the specific steps of glucose uptake and the relative contribution of skeletal muscle and adipose tissue to the lower peripheral glucose uptake in African American women. Muscle biopsies are obtained for mechanistic studies, including mitochondrial function, specific protein levels, histology, and tissue culture. Laboratory analyses include the use of gas chromatography – mass spectrometry. This project also includes examination of the role of mitochondrial DNA haplotype in racial differences in mitochondrial respiration, resting metabolic rate and aerobic fitness.
Another focus is to gain insight into the metabolic differences responsible for the high BMI and odds of obesity in Samoans associated with the recently identified CREBRF missense variant. To obtain a complete picture of energy balance, we will employ the doubly labeled water (DLW) method, indirect calorimetry, activity monitors, and dual energy x-ray absorptiometry (DXA). Longitudinal DLW and DXA measures allow for objective assessment energy intake. Laboratory analyses includes measurement of deuterium and 18-Oxygen isotope enrichment by isotope ratio mass spectrometry.
Monday through Friday; 8a – 5p
The Postdoctoral Research Scientist assists in the translational research at the Translational Research Institute and participates in Industry/NIH/Pharmaceutical and government sponsored and investigator initiated research that supports the TRI scientific research plan. Responsible for helping to develop a research program in their field area, and provides guidance to other support staff in the performance of protocol specific tasks. Helps to ensure that all research performed under their direction is in compliance with all AdventHealth, TRI, local, state, and federal laws, policies and procedures. Actively participates in outstanding customer service and accepts responsibility in maintaining relationships that are equally respectful to all.
We are one of the largest faith-based health care providers in the United States. For 150 years, we have carried on a tradition of providing whole-person care that not only addresses patients' physical ailments, but also supports their emotional and spiritual well-being. We demonstrate the same level of compassion and care for our employees as well, doing all that we can to help them realize their full potential – both personally and professionally.