Postdoctoral Scholar on the impact of cannabinoids across the lifespan
Open March 6th, 2019 through June 30th, 2019
A postdoctoral position is offered in a leading basic science neuropharmacology laboratory to study the effects of plant-derived cannabinoids on the endocannabinoid system in adolescent animals.
Teenagers use cannabis more than any other recreational drug. Evidence suggests that frequent cannabis use in adolescence may be associated with impairments in cognitive and affective functioning that continue in adult life. Excessive stimulation of the endocannabinoid system - the target of cannabis's main psychoactive component, ?9-tetrahydrocannabinol (THC) - is a plausible but still poorly understood mechanism for the long-lasting consequences of cannabis use. Our NIH-funded Center of Excellence utilizes multidisciplinary approaches to test the hypothesis that non-physiological activation of the endocannabinoid system in adolescence initiates an epigenetically driven reprogramming of the processes that govern the molecular structure, neuroanatomical architecture and synaptic functions of this system, ultimately producing persistent abnormalities in cognition and motivated behavior.
The successful candidate will use state-of-the-art liquid chromatography/mass spectrometry (LC/MS) and in vivo animal techniques to investigate how age affects the pharmacokinetics and pharmacodynamics of THC, and how THC influences endocannabinoid signaling in an age-dependent manner.
Candidates should have a recent PhD degree and hands-on experience in LC/MS, in vivo animal techniques (handling and drug injection) and must be highly motivated. Experience in lipid analysis and/or animal behavior is a plus.
The culturally diverse and welcoming laboratory is located on the UC Irvine campus, a rich community of pharmacological, molecular and neuroscience research in Southern California.
Please upload a CV, a brief statement of research accomplishments and interests, and contact information for 3 References.
The University of California, Irvine is an Equal Opportunity/Affirmative Action Employer advancing inclusive excellence. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, protected veteran status, or other protected categories covered by the UC nondiscrimination policy.
Since 1965, the University of California, Irvine has combined the strengths of a major research university with the bounty of an incomparable Southern California location. UCI's unyielding commitment to rigorous academics, cutting-edge research, and leadership and character development makes the campus a driving force for innovation and discovery that serves our local, national and global communities.