Pfizer colleagues have many perspectives, many backgrounds, and many strengths, but we share one goal: to improve the lives of patients. Worldwide Research and Development (WRD) combines research units that have deep disease area expertise with partner lines that deliver cutting-edge science, generating an efficient R&D operating model, to discover and develop innovative therapies.
The successful candidate will join a team of ~50 scientists within the Primary Pharmacology Group (PPG) at our Groton, CT campus, focused on the design, development, and execution of in vitro plate-based screening assays supporting hit identification and lead optimization for small molecule drug discovery programs across Pfizer Research Units. Disease areas of focus for the group include Inflammation and Immunology, Cardiovascular/Metabolic, Rare Diseases, and Oncology. Working collaboratively with project teams, (s)he will autonomously provide assay development and small molecule screening support to both target-based and phenotypic programs, ensuring support from project idea to clinical candidate selection.
Applicants must have experience working independently in a laboratory setting and a broad understanding of biology. Previous experience in 3 or more of the following is required: plate-based pharmacology, cell biology, biochemistry, enzymology, drug discovery, laboratory automation. Also critical to the role is a demonstrated ability to rapidly become proficient with new technologies, equipment and software (e.g. screening techniques and equipment, ABase, GraphPad Prism, Spotfire). The successful candidate will be excited by working in teams with multiple partners (e.g. Chemistry, Research Unit Biology, Structural Biology, and CROs). In addition to sound technical skills, the candidate should therefore possess strong collaborative and written/verbal communication skills, be adept at building partnerships, and display flexibility/resiliency and a good sense of humor.
At Pfizer, we believe in helping people lead healthier lives — from our customers to our colleagues. We offer a wide array of programs and plans that give our colleagues the flexibility and tools they need to get and stay healthy, both physically and financially. These include competitive compensation, generous medical, vacation and retirement benefits as well as a number of additional programs. The Primary Pharmacology Group offers a collegial and supportive environment for colleagues, with a culture encouraging openness, innovation and ownership of our science. We aim to provide scientific and growth opportunities for personal and career development commensurate with a colleague’s goals and experience.
We seek a laboratory scientist to support hit identification and lead optimization for small molecule drugs discovery projects.
This scientist will participate in designing in vitro pharmacology strategies for target-based and phenotypic projects. Working with the team, (s)he will develop, optimize, and perform in vitro assays to drive lead identification and SAR using a combination of biochemical, target-based, and physiologically relevant assay systems. (S)he will carry out data analysis as well as review and interpret this data for project teams.
This scientist will have the opportunity to work on cutting-edge science using novel technologies applied to portfolio advancement.
This scientist will work with an interdisciplinary team of Research Unit biologists, medicinal chemists, structural biologists and biophysicists, as well as external partners to deliver on the portfolio.
BS or equivalent with 6+ years of experience relevant to drug discovery in biochemistry, cell biology, and/or pharmacology OR MS with 5+ years of relevant industry experience
Demonstrated experience with several in vitro assay formats (e.g. FRET, FACS, FP, ELISA, high content imaging, FLIPR, radioligand binding, etc.), including troubleshooting
Practical experience with cell culture, laboratory automation, and data analysis systems
Demonstration of excellent computer, verbal and written communication skills
Previous experience in multiple target classes (e.g. GPCRs, transporters, kinases, ion channels,…) in a drug discovery setting
Knowledge of associated disciplines such as functional genomics, molecular and cellular biology, protein chemistry, biophysical techniques and chemistry.
Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.
EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.
Other Job Details:
Eligible for Employee Referral Bonus
Eligible for Relocation Package
Internal Number: 4749195
About Pfizer Inc.
Pfizer is a leading research-based biopharmaceutical company. We apply science and our global resources to deliver innovative therapies that extend and significantly improve lives. We make medicines and vaccines that help people when they are sick and prevent them from getting sick in the first place, as well as some of the world’s best-known consumer healthcare brands. Every day, our colleagues work in developed and emerging markets to treat, cure and eradicate life-threatening conditions and challenge some of the most feared diseases of our time. Pfizer also collaborates with healthcare providers, governments and local communities to support and expand access to reliable, affordable healthcare around the world. For more than 150 years, Pfizer has worked to make a difference for all who rely on us.
To learn more, visit www.pfizer.com. For additional information on our guidelines, please visit http://www.pfizer.com/community-guidelines