The fellowship will be available in either the Neurodevelopment or Mechanisms underlying Neuronal Activity/Secretion program area in the Cellular and Developmental Laboratory. Descriptions of the work and projects performed in either program area are below:
Neurodevelopment Description: Work encompasses Cell lineage, Neuronal Migration, Axonal Targeting and Craniofacial development. Projects focus on differentiation and migration of GnRH cells and olfactory axon outgrowth during development of the craniofacial region. Prenatally, GnRH neurons originate in the nasal region and migrate on olfactory axons into the brain. Current projects examine: 1) lineage of the GnRH cells, 2) axon targeting, 3) biology of genes identified in patients with delayed puberty and anosmia, and 4) development of the craniofacial region. Candidates with experience in mouse development, molecular and imaging techniques preferred but not mandatory.
Mechanisms underlying Neuronal Activity Description: Projects focus on the mechanisms underlying neuronal activity using GnRH neurons as the model system. In vivo, GnRH neurons, spread throughout the forebrain, release GnRH in a pulsatile fashion to control reproduction. In explants, primary GnRH neurons continue to release in a pulsatile fashion and show synchronized calcium oscillations. Projects utilize the GnRH system to study molecular and cellular properties of neuronal activity (individual cells and neuronal population dynamics) and correlate activity with secretion. Candidates with experience in calcium imaging or electrophysiology and mouse anatomy preferred but not mandatory.
The laboratory in which the candidate will work utilizes multidisciplinary approaches such as, cre/lox mice, immunocytochemistry, video microscopy, calcium imaging, electrophysiology in situ histochemistry, single-cell PCR, and subtractive cDNA screening.
The successful candidate must have an Ph.D., M.D. or D.O. degree or equivalent, and relevant training in Neurobiology, Neuroendocrinology, Molecular biology, or Developmental biology.
Internal Number: 1313
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